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Friday, 28 October 2022

Why fungus is considered as a threat in clean rooms as compare to bacteria whereas both are part of human microbial flora?

Both bacteria and fungus are part of normal human microbial flora. Bacteria are prokaryotic microorganisms whereas as fungi are eukaryotic. Bacteria are single celled microorganisms and fungus are multicellular microorganisms. 

In guidelines, acceptance limits are given grade wise for Settle plate, Volumetric air sampling, Surface monitoring and Personnel monitoring. But one thing is common in all guidelines that limits are given in form of total aerobic microbial count (TAMC) or viable particle contamination and it is not differentiating between bacteria and fungus. Then why fungus is considered as more critical than bacteria?

The reason is that fungus can contaminate the area in very destructive way as compare to bacteria. Fungus grow rapidly where is gets moisture and high RH. Fungus can grow on the surfaces easily. Fungus can easily spread through their spores and can contaminate the other areas of the facility. Fungus spores can become dormant for very long time and whenever it get favorable conditions it can grow easily. Fungal spores are more resistant then the vegetative cells. Whereas bacterial contamination can be controlled easily as compare to fungus. For all these reasons fungus is considered as a threat in clean rooms as compare to bacteria. 


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